Everything You Need to Know About the Acne Medication Spironolactone

Dermatologists say it's a hormonal acne fighter.

woman with acne
Stocksy

In recent years, the rise in cases of adult acne has been likened to an epidemic. More and more adults are having to deal with teenage skin long after blowing out the candles on that 19th birthday cake. Whether you’ve tried tweaking your diet (have you tried giving up dairy yet?) or switching up your skincare routine, it’s a really tricky skin issue to fix because the causes and fixes vary so wildly from person to person. In short, when it comes to acne, we’re still after some miracle cure. So when we heard that highly-respected dermatologists recommended the same spot-fighting ingredient within weeks of each other, our ears perked up. Besides, who could forget a catchy name like spironolactone?

Spironolactone

Type of ingredient: Medication

Main benefits: Regulates oil production, blocks androgen receptors, and reduces the length of hormonal breakouts.

Who should use it: In general, women with hormonal acne or women who have been resistant to other acne treatments in the past. It is not recommended for men or for women who are looking to become pregnant.

How much you should use it? Consult a dermatologist.

Works well with: Generally, it works well with all topical treatments.

Don't use with: Check for interactions with other medications.

What Is Spironolactone?

One of the reasons this ingredient has been lying low is because it can’t be applied topically. In fact, it’s an oral form of medication that was initially used to treat mild blood pressure and water retention. However, women with combination skin taking the drug for those aforementioned reasons soon found that one of the side effects was better skin—in particular, fewer spots and breakouts.

It’s been dished out in the United States for years to treat adult acne. Nick Lowe, MD, a consultant dermatologist and clinical professor, who practices out of the U.S. and England, says this is because prescribing spironolactone for acne is essentially “off-label,” meaning it wasn’t designed to treat hormonal acne, so it doesn’t sit neatly under that category.

Susan Raffy, a California-based cosmetic chemist and the president of Susan Raffy Consulting, says that those "off-label" prescriptions are typically reserved as a last resort. "If you do not suffer from Polycystic Ovarian Syndrome, Spironolactone is not prescribed for treating acne," says Raffy.

That being said, dermatologists, gynecologists, and endocrinologists have been using it for women suffering from PCOS for a while. “It’s not actually licensed for treating acne in absence of the full syndrome, but consultant dermatologists can prescribe the drug on an off-label basis for women who have a hormonal pattern to their spots and whose acne hasn’t responded to first-line therapies such as prescription creams, antibiotics, and even Accutane,” explains Justine Kluk, MD, dermatologist and acne specialist.

So, when women experiencing hormonal acne get wind of a treatment that works without any irritation to the skin or other nasty side effects (some lightheadedness can occur if you have low blood pressure), they might be quick to jump in. Which is why it’s now starting to gain traction as a treatment for women who have severe hormonal acne.

empty pill cartridge
Stocksy

Benefits of Spironolactone for Skin

• Clears skin by blocking hormones: It’s the impact spironolactone has on the hormones that give it its superpowers. That’s because it blocks the effect that androgens (hormones like testosterone) have on the body. Increased androgens can increase sebum production. Once you stop that, the acne glands and hair follicles won’t get overloaded, thus reducing the likelihood of developing pimples.

• Treats high blood pressure: This is, of course, the primary reason spironolactone is prescribed—it's a potassium-sparing diuretic (i.e. a water pill) that prevents the body from absorbing too much salt.

• Treats hair loss in women: Due to its impact on hormone regulation, the drug has recently been prescribed for women experiencing hair loss. It hasn't been found to have the same impact on men, however.

The trouble with spironolactone, however, is that androgens are notoriously tricky to target, which is why it doesn’t perform very well as a topical treatment: “Studies show it’s the same concept as Roaccutane in that it works when ingested via the mouth, but not when applied as a gel,” Lowe says.

The good news? The more people are talking about it and the more studies that can prove its complexion clearing abilities, the more likely it will start to become a go-to for dermatologists and doctors—especially when cases of adult acne are on the rise.

As Raffy explains, the reason that spironolactone works on acne is two-fold. "Testosterone causes the sebaceous glands in our skin to produce more oil and make our skin thicker resulting in increased clogged pores," she says. "By blocking the actions of testosterone on our skin, the risk of clogged pores and subsequent acne is reduced." 

Side Effects of Spironolactone

Because the drug tampers with hormone levels and testosterone, it’s recommended for use by women only (it could potentially cause men to suffer from gynecomastia, enlarged breast tissue and tenderness). It also can’t be prescribed for those who are trying to get pregnant, so bear this in mind if you’re planning to conceive any time soon.

Otherwise, the negative side effects associated with taking oral doses of Spironolactone include "electrolyte imbalance, breast tenderness, irregular periods and increase in urination," says Raffy. 

Dr. David Colbert, MD, and founder of the New York Dermatology Group, also recommends that people taking spironolactone stay hydrated, as it is a diuretic. "Also, it can alter your blood potassium levels, therefore, people with kidney disease should not take it," he says.

How Does It Work?

Like most skincare products, topical or oral, you have to give it time to work. Kluk says it takes around three months to see results. And just how promising are those results? In one study, 85% of patients saw an improvement in their acne, and 55% were completely clear of acne after taking spironolactone. The good thing is that there’s no time limit to how long you can take the drug, unlike the antibiotics that are often prescribed for acne.

Having said that, some dermatologists advise taking antibiotics at the same time, including Lowe. “If someone keeps coming back for acne because other treatments aren’t working, I’ll prescribe a low-dose antibiotic along with spironolactone, but that will soon be withdrawn and then they can remain on the spironolactone for long-term periods,” he adds. If you do find yourself on antibiotics, consider trying to bolster your gut bacteria (it can be adversely affected by antibiotics) with a probiotic like Symprove.

Lowe describes it as an “old medicine that’s been rediscovered for new uses,” so if you’ve tried everything from AHAs to giving up dairy and regular facials to prevent pustules, then this could be the ingestible answer you’ve been looking for. But, as always, remember: "Acne comes with bacteria and hormones, if [spironolactone] isn't working, speak to a doctor to see if they can add something topical/oral," Colbert says.

Shop our favorite acne-fighting products.

CeraVe Hydrating Cleanser
CeraVe Hydrating Cleanser $18
Shop

This no-frills cleanser will whisk away dirt and makeup without stripping the skin or exacerbating your acne. It's great for those with sensitive skin.

iS Clinical Active Serum
iS Clinical Active Serum $138
Shop

Whether you already have zits or feel them coming on, this exfoliating serum is a winning formula that makes light work of preventing and fighting blemishes—no matter how stubborn or angry they may be.

Salicylic Acid 2% Masque
The Ordinary Salicylic Acid 2% Masque $12
Shop

Stubborn under-the-skin acne and blocked pores? Salicylic acid gets in the pores and gently loosens and removes anything trapped inside.

Paula’s Choice 10% Niacinamide Booster
Paula’s Choice 10% Niacinamide Booster $44
Shop

Not only does niacinamide bolster your skin’s barrier function, but it is also anti-inflammatory, so it calms any inflamed, angry blemishes you may have. Layer this with other serums or add a couple of drops to your day cream.

La Roche-Posay Hyalu B5 Serum
La Roche-Posay Hyalu B5 Hyaluronic Acid Serum $30
Shop

Make sure your skin is sufficiently hydrated by adding in a lightweight hyaluronic acid-based serum.

La Roche-Posay Effaclar Duo
La Roche-Posay Effaclar Duo $30
Shop

Containing niacinamide, glycerin, and salicylic acid, this lightweight, hydrating lotion will calm blemishes and hydrate the skin. It’s an acne-fighting must-have.

Avène Cleanance Mask-Scrub
Avène Cleanance Mask-Scrub $24
Shop

This multitasking scrub mask contains AHAs (glycolic and lactic), salicylic acid to exfoliate, and cellulose beads meant to slough away dead skin. Soft kaolin clay promises to mop up excess oil, too.

Next up: All the advice you need to clear up your adult acne.

Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Kim GK, Del Rosso JQ. Oral spironolactone in post-teenage female patients with acne vulgaris: practical considerations for the clinician based on current data and clinical experienceJ Clin Aesthet Dermatol. 2012;5(3):37-50.

  2. Rathnayake D, Sinclair R. Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair lossDermatol Clin. 2010;28(3):611-618. doi:10.1016/j.det.2010.03.011

  3. Charny JW, Choi JK, James WD. Spironolactone for the treatment of acne in women, a retrospective study of 110 patientsInt J Womens Dermatol. 2017;3(2):111-115. doi:10.1016/j.ijwd.2016.12.002

  4. Levin J, Momin SB. How much do we really know about our favorite cosmeceutical ingredientsJ Clin Aesthet Dermatol. 2010;3(2):22-41.

Related Stories