An Honest Review of the Hydrating Vichy LiftActiv Supreme Serum 10

A hyaluronic acid serum for fine lines and firmness.

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Vichy LiftActiv Supreme Serum 10

vichy liftactiv serum 10 supreme

Byrdie / Joline Buscemi

What We Like
  • Absorbs into skin quickly

  • Uses fragmented hyaluronic acid

  • Mid-range price

What We Don't Like
  • Strong fragrance

  • Not vegan

Vichy LiftActiv Supreme Serum 10 hydrates and plumps fine lines, but stay clear if you’re sensitive to fragrance.


Vichy LiftActiv Supreme Serum 10

vichy liftactiv serum 10 supreme

Byrdie / Joline Buscemi

We put the Vichy LiftActiv Supreme Serum 10 to the test after receiving a complimentary sample from the brand. Keep reading for our full product review. 

By now, there are a ton of hyaluronic acid serums to choose from with price points from the lowest of low to the incredibly high. Vichy LiftActiv Supreme Serum 10 is somewhere in the middle, and like similar serums, promises plumper, more hydrated skin.

If you’re new to hyaluronic acid (HA), first you should know that it’s already naturally present in our bodies. As a topical, it works by attracting water (somewhere around 1000 times its weight) which in turn hydrates skin and gives you all the benefits of plumped skin. There are tons of products that include HA, mostly serums that can play well in most skincare routines.

Whether you’re trying an HA for the first time or you’re looking for something new, the Vichy LiftActiv Supreme Serum 10 might be one you have your eye on. Is it worth it? I tested it, and here are my thoughts.

Vichy LiftActiv Supreme Serum 10

Best for: Dry, or mature skin

Uses: Hydration, fine lines, firming skin

Potential allergens: Fragrance

Active ingredients: Hyaluronic acid, rhamnose

Byrdie Clean?: No

Cruelty-Free?: No

Price: $45

About the brand: Vichy has over 80 years of experience developing skincare products alongside dermatologists and skincare experts.

About My Skin: Keeping it hydrated

Over the years I’ve seen signs of aging creeping in—fine lines where there weren’t any before, and a slight loss of elasticity. Keeping my skin hydrated helps, so I like to use products that moisturize without causing my breakout-prone skin to react.

I used the serum right out of the shower since HA works best when applied to damp skin. Depending on the day, I either applied a moisturizer on top right away or waited until later to use my tretinoin prescription and then moisturizer. You can use the HA serum morning and night, however, I used it solely in the evenings.

 The Feel: Sinks in but leaves a scent

Ther serum is iridescent white and silky and spreads smoothly over the skin. It disappears nearly instantly, and the only evidence it was ever on is that hydrated skin it leaves behind. Moisturizer, makeup, or any other skincare products can be applied on top immediately after without disturbing the other.

The only negative I have about the application was the scent. It smells artificial and perfume-like, which may not bother you but wasn't my favorite. The scent disappears within ten minutes, but those with sensitive skin may still find it irritating. 

vichy liftactiv serum 10 supreme

Byrdie / Joline Buscemi

The Results: Plumped up skin

The formula has 10% rhamnose, a plant sugar, which improves skin structure and aids healthy aging. Meanwhile, fragmented hyaluronic acid hydrates and plumps skin. Because the HA is fragmented, aka broken into tinier bits, it more easily penetrates deeper layers of skin.

The brand claims that a difference can be seen in 10 days. I decided to focus on the fine lines in my forehead and ever-growing lines between my brows and applied the serum to my skin every night.

After a week and a half, I did feel like my skin was firmer and that the lines may have decreased, but it wasn’t a huge difference quite yet.

Over a longer period the results may become more pronounced, and keeping the skin hydrated can keep those lines from forming in the first place.

vichy liftactiv serum 10 supreme

Byrdie / Joline Buscemi

The Value: A mid-range HA product

The serum sells for around $45 for the 1-ounce bottle. This is about in the middle when compared to similar serums that contain HA, which can range from under $10 to the $300 bottle from Dr. Barbara Sturm. There are several other serums around this price that contain more beneficial ingredients in a possibly better formulation, so in my opinion, this is as much as I would want to pay for a serum like this.

vichy liftactiv serum 10 supreme

Byrdie / Joline Buscemi

Similar Products: A lot to choose from

Good Molecules Hyaluronic Acid Serum ($6): This is a super light HA serum that’s also super affordable. It has three different HA molecule sizes (but it doesn’t contain any other special ingredients). The best part? It’s only $6 for the same sized bottle as Vichy’s serum.

Glow Recipe Plum Plump Hyaluronic Acid Serum ($42): Different molecule sizes mean that this HA serum can impact several layers of skin–and this one has five. It’s also formulated with plum for antioxidants, collagen, and protein.

Final Verdict

There are less expensive alternatives, however, so if you find good results with those you may want to stick with those, especially if you’re sensitive to fragrance in your skincare. But with that said, Vichy LiftActiv Supreme Serum 10 hydrates the skin well thanks to rhamnose and a boost of HA.


  • Product Name LiftActiv Supreme Serum 10
  • Product Brand Vichy
  • SKU 3337875604796
  • Price $45.00
  • Weight 1 oz.
  • Ingredients Aqua, Rhamnose, Cyclohexasiloxane, Glycerin, Alcohol Denat. , Butylene Glycol, Polymethylsilsesquioxane, Octyldodecanol, Polysilicone-11, Dimethicone, Pentaerythrityl Tetraethylhexanoate, Bht, Peg-20 Methyl Glucose Sesquistearate, C13-14 Isoparaffin, Sodium Hyaluronate, Sodium Hydroxide, Adenosine, Poloxamer 338, Di Sodium Edta, Ammonium Polyacryldimethyltauramide, Tocopherol, Capryloyl Salicylic Acid, Caprylyl Glycol, Hydrolyzed Hyaluronic Acid, Laureth-7, T-Butyl Alcohol, Polyacrylamide, Parfum
Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Sudha PN, Rose MH. Beneficial effects of hyaluronic acidAdv Food Nutr Res. 2014;72:137-176. doi:10.1016/B978-0-12-800269-8.00009-9

  2. Jiang N, Dillon FM, Silva A, Gomez-Cano L, Grotewold E. Rhamnose in plants - from biosynthesis to diverse functions [published correction appears in Plant Sci. 2021 Jun;307:110897]. Plant Sci. 2021;302:110687. doi:10.1016/j.plantsci.2020.110687

  3. Bukhari SNA, Roswandi NL, Waqas M, et al. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effectsInt J Biol Macromol. 2018;120(Pt B):1682-1695. doi:10.1016/j.ijbiomac.2018.09.188

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