Tepezcohuite for Skin: Benefits and How to Use

Salma Hayek

Dimitrios Kambouris / Getty Images

There's no denying that Salma Hayek has the face of an angel. She's ageless. Now in her 50s, the Mexican actress has the skin we dream of having at any age. And whenever people look as youthful and fresh-faced as they did 20 years prior, we are desperate to know their antiaging secret. So we were highly intrigued when Hayek revealed in an interview that she doesn't use Botox, pills, or fillers—and that her secret weapon is instead a Mexican botanical called tepezcohuite (sometimes also called tepescohuite in scientific journals). "It's used in Mexico for burn victims because it completely regenerates the skin, and there's no one in the States who is using this ingredient," she told Elle.

Meet the Expert

  • Patricia Farris, MD, is a board-certified dermatologist who is known for her holistic approach to anti-aging treatments.
  • Rajani Katta, MD, is a board-certified dermatologist who serves as a Voluntary Clinical Faculty of both the Baylor College of Medicine and the McGovern Medical School, University of Texas Houston.
  • Vanessa Thomas is a cosmetic chemist with over a decade of product formulation experience.

If life were a cartoon, that would have been the moment our wheels revved in place until we sped off in search of all of the tepezcohuite ever to slather over our faces 10 times a day until the end of time. Naturally, we had to know more about this little-known, exotic ingredient Hayek says is responsible for her flawless skin. So, we spoke with dermatologists Patricia Farris and Rajani Katta, and cosmetic chemist Vanessa Thomas, for their takes on tepezcohuite.


Type of ingredient: Anti-microbial.

Main benefits: Moisturizes, and could potentially promote burn- and wound-healing.

Who should use it: In general, anyone with dry or irritated skin.

How often can you use it: Not enough scientific studies have been conducted to determine appropriate usage.

Works well with: Aloe and tea tree oil.

Don’t use with: Harsh exfoliators such as glycolic acid, and astringents, as doing so may irritate the skin.

What is Tepezcohuite?

Also known as "mimosa tenuiflora," tepezcohuite is a bark tree found in Southern Mexico that resembles a fern. The tree does well at regenerating itself in the aftermath of forest fires, and natives of Mexico refer to it as the "skin tree." It was administered by the Mayan culture thousands of years ago to treat skin lesions such as burns, by grinding the bark up into a powder. In 1984, after a horrific gas explosion in Mexico City killed 500 and left more than 5000 with severe burns, the Red Cross treated the burn patients with tepezcohuite. It was so effective at healing their wounds and regenerating the skin that a year later, when an earthquake caused a series of explosions and fires, tepezcohuite was again used to treat victims. 

Benefits of Tepezcohuite for Skin

Tepezcohuite is purported to have plenty of benefits, all of which some say make it a skincare miracle. However, because it hasn't been widely adopted by the west, scientific studies to determine exactly all the ways tepezcohuite works are sorely lacking. Most of the evidence to the efficacy of this not-yet-hyped ingredient is anecdotal.

  • Antibacterial properties: "Tepezohuite is known for its antibacterial activity and has been used for wound healing," says Farris. Thomas notes that some research has shown that the bark has anti-microbial and wound healing properties, but "it is not very efficacious against anti-fungal effects."
  • Could possibly reduce scars: Anecdotal evidence suggest it's been effective in reducing scars, though experts are quick to point out that it hasn't undergone many scientific studies.
  • Is a potential anti-aging ingredient: Farris explains, "The bark of the tree has also been made into an extract and formulated into anti-aging creams. It’s important to say that none of the anti-aging products with tepezcohuite have been studied in human clinical trials so at this point we really don’t know if has any beneficial effects on the skin."
  • Antioxidant and anti-inflammatory ingredient: Farris adds that certain compounds in the bark could be of value in treating aging skin. "It has flavonoids that are powerful antioxidants that can benefit skin by neutralizing free radicals," she notes. "Free radicals cause oxidative stress in the skin and contribute to skin aging. It’s important to understand the all plants have antioxidants in them, which is why you find so many botanical ingredients in skincare products. The bark extract also has tannins, which are antioxidant and anti-inflammatory compounds so they may provide a soothing or calming effect on the skin.
  • Improve skin barrier: Tepezcohuite can potentially help strengthen your moisture barrier. Farris adds, "It also contains lipids that could benefit skin by improving skin barrier function."

Side Effects of Tepezcohuite

Because it has been studied so little, the jury's still out on whether or not tepezcohuite has any side effects. "Because this ingredient has not been studied we don’t know if there are any other products to avoid or not use it with," cautions Farris. "As for negative side effects, this has also not been studied. It does cause birth defects in ruminant animals that graze on this tree and has psychoactive compounds that that may also be of concern." 

"This bark has been notoriously used in Mexican and South American remedies and products," says Thomas. "Unfortunately, there are no actual clinical trials that have been conducted for this extract, so that actual side effects and information in regards to usage requirements have not been established."

Katta goes one step further, saying that its long history of use in South America isn't compelling enough to recommend it for everyday use. "We lack clear research on who might benefit and the risk of potential side effects such as allergic reactions," she says. "While it has shown some promise in laboratory studies, we have very limited research in humans, and the research we do have has not been promising. A small study with human volunteers found that a hydrogel containing this ingredient worked no better than a hydrogel without it when it came to healing of the leg ulcers."

How to Use It

Tepezcohuite extract can be found in a number of skincare products, including serums, moisturizers and oils.

As the safety of products that contain tepezcohuite has not been verified, Thomas advises "the restriction of usage until more clinical data can be obtained on this if the consumer is pregnant or nursing. You can consult with a licensed health professional, but as there are not much conclusive data surrounding this extract, the answer may not be definitive. As with any new extract or product, just because it is plant-based does not mean it is necessarily safe for human consumption especially in combination with other ingredients."

The Best Products With Tepezcohuite

ASDM Tepezcohuite cream
ASDM Beverly Hills Tepezcohuite Cream $25.00

This ultra-healing cream is especially helpful after an AHA or BHA peel and helps soothe skin and balance PH. It's also a solid choice for men, as it's been found to calm skin irritation, post-shave.

Life Elements Body Oil
Life Elements CBD and Tepezcohuite Body Oil $8.00

A hydrating, natural, and non-greasy formula for use on skin rashes, fine lines, dark spots and dry patches. Spiked with CBD, the product also helps with inflammation and soreness.

ASDM tepezcohuite serum
ASDM Beverly Hills Tepezcohuite Serum $30.00

Highly potent and meant to be used in conjunction with the brand's tepezcohuite cream, this serum claims to have anti-inflammatory properties that can help soothe sensitive skin.

ASDM Tepezcohuite Microdermabrasion
ASDM Beverly Hills Tepezcohuite Microdermabrasion Cream $25.00

This granular facial scrub is packed with antimicrobial tea tree oil, aloe to soothe, and a host of other good-for-you ingredients (think grapeseed and camellia seed oil).

Tepezcohuite body lotion
ADSM Beverly Hills Tepezcohuite Body Lotion $30.00

Ingredients like mango and aloe sooth damaged skin, while tepezcohuite and camelia seed oil nourish and moisturize.

LaVigne Natural Skincare
LaVigne Natural Skincare Mayan Magic Balm $28.00

This soothing balm combines tepezcohuite and shea butter to relieve itch and calm skin post-rash or trauma. It's also paraben- and scent-free, so it's ideal for sensitive skin.

  • What is tepezcohuite?

    Tepezcohuite is bark tree found in Southern Mexico that resembles a fern. It has been used for centuries to treat burns and other skin lesions.

  • Can tepezcohuite help with acne?

    There are not enough studies to conclusively say that tepezcohuite is effective at treating acne.

  • Is tepezcohuite safe to use on skin?

    While anecdotal evidence says that tepezcohuite is safe and effective to use on skin, there have not been many studies conducted on it to establish any side effects.

Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Lammoglia-Ordiales L, Vega-Memije ME, Herrera-Arellano A, et al. A randomised comparative trial on the use of a hydrogel with tepescohuite extract (Mimosa tenuiflora cortex extract-2G) in the treatment of venous leg ulcers. Int Wound J. 2012;9(4):412‐418. doi:10.1111/j.1742-481X.2011.00900.x

Related Stories