7 Long-Term Effects of Botox You Need to Know

Closeup of blonde woman getting a botox injection


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Ever since the invention of Botox in the 1980s, women and men everywhere have been obsessed with the injectable to cheat the aging process—aesthetically, at least. How does it work?

Botox is a neurotoxin that temporarily "prevents the communication between your nerves and your muscle," explains dermatologist Mara Weinstein, M.D. In other words, Botox paralyzes the injected muscle, usually for a period of three to six months. "Therefore, if you try to frown, you won’t be able to, which is not a bad thing," says Weinstein. She adds that some studies have actually shown that regular treatments with the neurotoxin can enhance mood and fight depression.

For anti-aging purposes specifically, doctors use Botox to treat two types of wrinkles: static and dynamic. Static lines are the deep wrinkles that are etched into people's faces after several decades of frowning, smiling, and raising their eyebrows, while dynamic wrinkles are only visible as you're making a facial expression. "The goal of treatment is to prevent the formation of static lines altogether," Weinstein says. "However, if you already have static lines, regular treatments with neurotoxin (and filler) can certainly soften the appearance and in some cases, eliminate them in the long run."

Here's the thing, though: Because the drug has only been around for 30 years, there aren't a lot of stories about the long-term effects of Botox. To find answers, we consulted top dermatologists.

Curious about the effects that Botox can have on your skin after 10 or more years of use? Just keep scrolling.

Your Facial Muscles Will Learn Not to Frown Naturally

After using Botox continuously for years, your muscles will become trained not to make wrinkle-forming expressions as aggressively. This works two ways: First, Weinstein says, "Once you are used to the feeling of having less movement in the forehead after neurotoxin, you will be more aware of making the movement when the toxin wears off."

Becoming more consciously aware of your expressions will help you avoid excess frowning, squinting, and eyebrow-raising moving forward.

How Does Botox Work
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The Muscles Will Weaken From Lack of Use

If you didn't move your legs for 20 years, eventually those muscles would shrink and become quite weak. The same thing can happen to the muscles in your face. "If used regularly, over a prolonged period of time, without interruption, eventually the muscle will atrophy from lack of use," says the legendary dermatological surgeon Patricia Wexler, M.D. That's not to say your entire face will atrophy. "As the Botox is injected in discrete locations on the face, eventually only those treated muscles will atrophy, leaving other muscles to maintain full volume," Wexler maintains.

So, no, your face isn't going to look stone-cold, according to Dr. Michele Farber of Schweiger Dermatology Group in New York City. "There are plenty of muscles that are working full time to allow for normal facial expression." She adds, "If given a break from Botox, muscles will regain strength." she says.

Meet the Expert

  • Patricia Wexler, M.D. is a renowned dermatologist and founder of the Wexler Dermatology Group known worldwide for pioneering tumescent liposuction and fat transplantation.
  • Dr. Michele Farber, MD, is a board-certified dermatologist with the Schweiger Dermatology Group. Her expertise includes general, cosmetic and procedural dermatology, as well as skin cancer.

Your Skin Might Become Visibly Thinner

Wexler says that some patients complain of a visible thinning of the skin after many years of Botox use. That might mean exposure of subdermal veins between areas of normal thickness. This isn't common, but Wexler says that patients who start Botox "too early," like in their early 20s, can be at risk for this side effect. In these cases, "The skin of the forehead [can] get prematurely thinner, and muscles weaker," she says. Sometimes, after many years of use, this can even result in the look of heavier brows and eyelids, "making the toxin actually more difficult to continue using."

"Discussing a proper skin regimen and integrating daily sunscreen can reduce this risk," Farber says.

Claudine Penedo

Mild Discoloration or a "Wavy" Texture Could Appear

Again, not typical, but Wexler says that with the skin thinning, some patients notice "a visible waviness of the skin overlying the muscles treated," as well as discoloration. "On expression, the forehead may even appear like hills and valleys," she says.

Luckily, this side effect is totally preventable. "[It] can be avoided by changing the pattern of injection to give smaller amounts of toxin in a more uniform distribution to get an identical effect without this problem, or stopping the toxin for an extended period of time," Wexler says.

You May Need Less Botox Over Time

Years of Botox use may mean you'll need less and less for maintenance over time. "With appropriate frequency and amount, your muscles become less strong and you may not need as much Botox or need it as frequently," Farber says. "When your muscles are 'trained' not to move, it helps with the aging process and preventing wrinkles." 

You'll Still Look Years Younger Even If You Stop

"Many people fear that their faces will become dramatically wrinkled when they stop Botox. If you choose not to continue…those muscles staying out of use while Botox is active can delay the aging process; it reduces movement when injected, slowing the formation of wrinkles," Farber explains. In other words, your skin won't develop lines overnight to make up for lost time—you'll still enjoy looking years younger relative to your age, depending on how long you kept a Botox regimen.

Skin Will Look Brighter and Less Wrinkled

Aside from what can happen after long-term use of Botox, one thing is for sure: "If you continuously get Botox for 10+ years you will certainly look much younger and have fewer wrinkles," promises Debra Jaliman, M.D., a New York City–based dermatologist and author of Skin Rules: Trade Secrets from a Top New York Dermatologist. "Your skin will look much smoother and the appearance of fine lines and deep wrinkles will be greatly diminished."

Debra Jaliman, M.D. is a board-certified dermatologist in New York, specializing in cosmetic and medical dermatology.

Weinstein agrees, adding, "You can age gracefully without having any wrinkles on the forehead, glabella, or around the eyes, when you may have had the propensity to develop them. That’s the beauty of Botox." (FYI, the glabella is that smooth part of your forehead above and between your eyebrows.)

Not quite sure if Botox is your thing? Get younger-looking skin at home by trying Fillerina, the Byrdie-approved Dermo-Cosmetic Gel Filler.

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