An Investigation: Can You Use Hydrocortisone Cream to Treat a Pimple?

hydrocortisone cream for acne


We've all been there. Your skin is behaving beautifully, clear and calm, with no blemishes in sight. You applaud yourself for finally nailing the perfect skincare routine, post IG stories with no filter, and rock the no-makeup look like no one's business. And then, wham. When you least expect it, a huge, honking pimple pops up out of nowhere. In times like these, there's an unsuspecting ingredient that you can use as a fast and effective spot treatment—and it's one you may already have squirreled away somewhere in your bathroom. We're talking about hydrocortisone cream. Ahead, dermatologists explain exactly how hydrocortisone works, and exactly how you should use it.

Meet the Expert

Keep reading to learn more about the ingredient that helps those pesky pimples.


Type of ingredient: Corticosteroid (anti-inflammatory)

Main benefits: As a spot treatment, it reduces redness and inflammation from breakouts.

Who should use it: Anyone (who isn't allergic to the ingredient) looking to target a specific inflamed breakout, rather than an area of the face.

How often can you use it: Apply no more than twice daily for a few days.

Works well with: Benzoyl peroxide, salicylic acid, sulfur, and retinoids.

Don’t use with: Other hydrocortisone products or on cortisone injection sites.

What is Hydrocortisone?

"Hydrocortisone is a corticosteroid, a medicine that reduces inflammation," explains Zeichner. It's a common anti-inflammatory treatment for skin conditions such as eczema or psoriasis, adds Carqueville, and is available both over-the-counter and as a prescription. (A one-percent concentration is the maximum strength available without a prescription). And to the over-the-counter point, it's often a go-to treatment for itchy, irritated, skin problems—think bug bites, rashes, poison ivy, and the like.

On the acne front, you may have heard of dermatologists using cortisone injections to quickly calm large, angry pimples. While both cortisone and hydrocortisone belong to the same family of corticosteroids, cortisone has to be converted to hydrocortisone in the liver, and won't work topically (hence the injection part). Still, over-the-counter hydrocortisone may offer a similar benefit to the injectable cortisone, says Zeichner. To that point...

Hydrocortisone for Acne

It's important to first point out that, because hydrocortisone works by combating inflammation, "it's not meant for blackheads or whiteheads, but rather for red, angry, underground pimples," says Carqueville. It's also not something you should be using across your entire face; instead, it's best for super targeted spots and used for only short amounts of time (more on both points in a moment). However, it definitely is effective at combating inflammation. It works particularly well when paired with not only benzoyl peroxide, but also salicylic acid, sulfur, and retinoids: "These ingredients work together to reduce the causes of an inflamed pimple—the oil at the skin surface, the clogging of the pore, and the acne-causing bacteria P. acnes," explains Carqueville. However, it's worth noting that when choosing over-the-counter hydrocortisone for blemish-busting purposes, it's important to seek out a cream formula, rather than an ointment. The occlusive texture of an ointment can be inherently pore-clogging, says Carqueville.

How to Apply Hydrocortisone

As mentioned, it's going to work best when paired with other ingredients. Try Zeichner's homemade spot treatment and combine a one-percent over-the-counter hydrocortisone cream plus a product containing two percent salicylic acid plus a product containing two-and-a-half percent benzoyl peroxide (use equal parts of each). Dab this concoction directly onto the pimple. Carqueville suggests first washing your face with a sulfur-based cleanser, then layering the hydrocortisone under a five-percent benzoyl peroxide product in the morning. Repeat this in the evening, swapping the benzoyl peroxide product for one with either a two-percent salicylic acid product or an over-the-counter retinoid. In either scenario, this is meant to be a short-term, quick-fix, and not a regular part of your skincare routine.

Side Effects

So why should hydrocortisone use be limited? "Overuse of topical steroids can lead to thinning and discoloration of the skin," cautions Carqueville. She advises using hydrocortisone on a blemish no more than twice daily, for two days max. Zeichner also warns about the overuse of topical steroids (though says you can use hydrocortisone on a blemish for up to two weeks). In an ironic twist, another possible side effect can be even more pimples: "Steroid acne is a well-described phenomenon where continuous use of topical steroids causes acne," says Zeichner. Overuse can also lead to steroid-induced dermatitis, perioral dermatitis specifically, which manifests as a red, bumpy rash around your nose and mouth, adds Carqueville. No, thank you.

The Best Products with Hydrocortisone

Aveeno Active Naturals 1% Hydrocortisone Anti-Itch Cream $5.00

Along with hydrocortisone, this also boasts a triple oat complex; colloidal oats are a choice skin soother to help further reduce inflammation, says Zeichner. The formula also boasts soothing aloe and vitamin E.

PCA Skin CliniCalm 1% $52.00

Aloe, linseed oil, honey, and hyaluronic acid make this nice and moisturizing, helping to combat the dryness that can often occur when you're trying to knock out a pimple. (And that can come from the other blemish-busting ingredients you may be pairing it with). It's a bit pricey yes, but one tube lasts forever, and since hydrocortisone can be used for so many things, you are getting a good bang for your buck.

CeraVe Hydrocortisone Anti-Itch Cream $9.00

Dermatologists love this brand for its use of ceramides, which play an essential role in keeping your skin barrier strong and healthy. They're found in this OTC hydrocortisone as well, making this an especially great pick if you're looking for a product that you can use not only as an emergency spot treatment but also to tamp down eczema flares.

Cortizone Cortizone-10 Maximum Strength Hydrocortisone Anti-Itch Cream $6.00

A drugstore staple, this option is readily-available and rings in at a very wallet-friendly price tag. It's non-greasy, penetrates quickly, and also contains skin-calming aloe.

Vanicream 1% Hydrocortisone Anti-Itch Cream $10.00

Vanicream is another brand beloved by derms, given that their products are geared towards sensitive skin. Case in point: This formula is fragrance-, paraben-, and dye-free, all common irritants. Plus, it's also non-comedogenic, so you don't have to worry about it clogging pores.

  • What is hydrocortisone cream used for?

    It's a common anti-inflammatory treatment for skin conditions such as eczema or psoriasis, says Carqueville, and reduces redness and inflammation from breakouts when used as a spot treatment.

  • When shouldn't you use hydrocortisone cream?

    You shouldn't combine with hydrocortisone products or on cortisone injection sites.

  • Can you use too much hydrocortisone cream?

    You should apply no more than twice daily for up to two weeks.

Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Hydrocortisone topical: uses, side effects, interactions, pictures, warnings & dosing - webmd.

  2. Gabros S, Nessel TA, Zito PM. Topical corticosteroids. In: StatPearls. StatPearls Publishing; 2021.

  3. Corticosteroids. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases; 2012.

  4. Meckfessel MH, Brandt S. The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care productsJ Am Acad Dermatol. 2014;71(1):177-184. doi:10.1016/j.jaad.2014.01.891

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