The 16 Best Retinol Serums of 2022

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Best Retinol Serums

Byrdie / Chloe Jeong

When it comes to tackling just about any skin problem—from fine lines and dark spots to uneven texture and breakouts—retinol is where it's at. It's one of a few vitamin A derivatives (aka retinoids) you can buy over the counter, often in the form of a serum.

Retinoids work by increasing cell turnover, offering mild exfoliation, and stimulating collagen production, explains board-certified dermatologist Diane Madfes, MD. "Retinol regulates our sebum production, which is great for acne control," she adds. "When used consistently, we also see a decrease in sun damage in the top layers of our skin."

Those clinically proven results are why retinol reigns supreme in the world of skincare. But which formula is right for you? We rounded up standout options touted by dermatologists, as well as a few fan favorites from the Byrdie team.

These are the best retinol serums you can order online.

Best Overall: Peter Thomas Roth Retinol Fusion PM Night Serum

4.7
Peter Thomas Roth Retinol Fusion PM Night Serum

Amazon

What We Like
  • Time-release formula

  • High retinol concentration

  • Dermatologist-recommended

What We Don't Like
  • Expensive

  • Small amount

What do buyers say? 82% of 1,000+ Amazon reviewers gave it 4 stars or above.

While over-the-counter formulas aren’t as strong as the prescription variety, Fusion PM holds its own. “I like this because the retinol is encapsulated and combined with vitamins C and E,” says Dr. Madfes.

This serum flaunts a generous 1.5 percent concentration of encapsulated retinol, meaning it releases slowly into your skin to sidestep irritation. In addition to the brightening antioxidants Dr. Madfes mentioned, she notes that the base is “very hydrating” thanks to the blend of humectants and skin-loving squalane, so you’re less likely to notice any dryness and inflammation from the retinol.

Price at time of publish: $65

Active Ingredients: Encapsulated retinol, vitamin C, vitamin E, squalane | Retinol Concentration: 1.5% | Dosage: A few drops nightly | Size: 1 oz | Cruelty-Free: No | Byrdie Clean: Yes

peter thomas roth retinol fusion pm night serum

 Byrdie / Olivia Hancock

What Our Testers Say

"I am happy to report that my skin is the smoothest it's ever been, and it looks refreshed all-around. Most importantly, this serum lived up to its claim of being gentle as I experienced no irritation or redness while using it." Olivia Hancock, Product Tester

Best Budget: The Inkey List Retinol Serum

The Inky List Retinol Serum

Walmart

What We Like
  • Budget-friendly

  • Award-winning formula

  • Non-irritating

What We Don't Like
  • Results aren't dramatic

If you're on a budget, go with this option from The Inkey List. This brilliantly cheap serum contains a 1 percent concentration of stabilized retinol, 0.5 percent of granactive retinoid (the gentle cousin of prescription-only tretinoin), and squalane to deliver moisture while minimizing irritation.

Price at time of publish: $17

Active Ingredients: RetiStar stabilized retinol, granactive retinoid, squalane | Retinol Concentration: 1.5% | Dosage: Pea-sized amount nightly | Size: 1 oz | Cruelty-Free: Yes | Byrdie Clean: No

Best Drugstore: Neutrogena Rapid Wrinkle Repair Serum

Neutrogena Rapid Wrinkle Repair Serum

 Courtesy of Neutrogena

What We Like
  • Budget-friendly

  • Noticeable results

  • Lightweight

What We Don't Like
  • Contains synthetic fragrance

"I recommend Neutrogena Rapid Wrinkle Repair Serum because it contains stabilized retinol, and the formulation won't break you out," says board-certified dermatologist Joshua Zeichner, MD. In a clinical trial commissioned by the brand, 100 percent of users noticed an improvement in their skin after just a week.

Price at time of publish: $21

Active Ingredients: Stabilized retinol, hyaluronic acid | Retinol Concentration: 0.3% | Dosage: Pea-sized amount daily | Size: 1 oz | Cruelty-Free: No | Byrdie Clean: No

Best Splurge: iS Clinical Pro-Heal Serum Advance +

Shari Darden
What We Like
  • Brightening

  • Calms inflammation

  • Reduces appearance of scars

What We Don't Like
  • Expensive

Charlene DeHaven, MD, says this advanced serum is an excellent spot treatment for inflammation and blemishes. "It contains high levels of wound healers for acne lesions, anti-inflammatories, and antioxidants from botanical sources," she tells Byrdie. "This strong serum is also packed with vitamins A, C, and E and olive leaf extract."

Price at time of publish: $158

Active Ingredients: Retinol, vitamin C | Retinol Concentration: Not listed | Dosage: A few drops daily | Size: 1 oz | Cruelty-Free: Yes | Byrdie Clean: Yes

Best Overnight: Sunday Riley Luna Sleeping Night Oil

sunday-riley-luna-sleeping-night-oil

Sephora

What We Like
  • Noticeable results

  • Calms inflammation

  • Moisturizing

What We Don't Like
  • Expensive

  • Small amount

Get your beauty sleep with Sunday Riley Luna. This overnight oil boasts an active retinoid complex, calming chamomile, and skin-loving plant oils like blue tansy, which contains azulene—one of the most potent skin-soothing ingredients on the market.

Price at time of publish: $47

Active Ingredients: Trans-retinoic acid ester complex | Retinol Concentration: Not listed | Dosage: A few drops nightly | Size: 0.5–1.2 oz | Cruelty-Free: Yes | Byrdie Clean: Yes

Best High Concentration: Yeouth Retinol Serum

Yeouth Retinol Serum

Amazon

What We Like
  • Budget-friendly

  • Encapsulated retinol

  • Firming

What We Don't Like
  • May be too strong for sensitive skin

With 2.5 percent encapsulated retinol, this serum offers one of the highest concentrations you can get over the counter, while encapsulation allows for a slow release with minimal irritation. As Dr. Madfes explains, it creates a firming effect by activating the retinoid receptors within our skin, which "stimulates collagen and elastin production."

Price at time of publish: $17

Active Ingredients: Encapsulated retinol, hyaluronic acid | Retinol Concentration: 2.5% | Dosage: Pea-sized amount daily | Size: 1–2 oz | Cruelty-Free: Yes | Byrdie Clean: Yes

Best for Crow's Feet: Dr. Dennis Gross Skincare Ferulic + Retinol Triple Correction Eye Serum

4.5
Dr. Dennis Gross Skincare Advanced Retinol + Ferulic Triple Correction Eye Serum

Sephora

What We Like
  • Non-irritating

  • Noticeable results

  • Dermatologist-developed

What We Don't Like
  • Expensive

According to Dr. Dennis Gross, a board-certified dermatologist and dermatologic surgeon, this eye serum is meant to be "applied both under the lid and on top for a lifting effect and incorporates retinol for treating crow's feet, fine lines, and 11s." What's more, he says the gel-like consistency offers a cooling, depuffing effect.

Price at time of publish: $69

Active Ingredients: Retinol, bakuchiol, ferulic acid | Retinol Concentration: Not listed | Dosage: Half a pump morning and night | Size: 0.5 oz | Cruelty-Free: Yes | Byrdie Clean: Yes

Best Capsules: RoC Retinol Correxion Smoothing Night Serum Capsules

RoC Retinol Correxion Smoothing Night Serum Capsules

Amazon

What We Like
  • Reasonably priced

  • Biodegradable

  • Dermatologist-recommended

What We Don't Like
  • Small supply

A favorite of Dr. Madfes, RoC Night Serum Capsules boast a high concentration of pure retinol. In a clinical trial, 100 percent of people noticed a reduction in fine lines and visibly firmer skin after just four weeks of using the ceramide-infused anti-ager. This might be why it’s Amazon’s second best-selling face serum.

Price at time of publish: $24

Active Ingredients: Retinol, ceramides | Retinol Concentration: Not listed | Dosage: One capsule nightly | Size: 30 capsules | Cruelty-Free: No | Byrdie Clean: Yes

Best Exfoliating: Shani Darden Retinol Reform Treatment Serum

Shani Darden
What We Like
  • Award-winning formula

  • Contains an AHA

  • Non-irritating

What We Don't Like
  • Expensive

  • Small amount

As Dr. Madfes explains, "All retinoids increase cell turnover." But Shani Darden's Byrdie-approved Retinol Reform takes it a step further. It calls on alpha-hydroxy acid to gently slough off dead cells, brighten your complexion, and improve uneven texture.

Price at time of publish: $88

Active Ingredients: Encapsulated retinol, lactic acid | Retinol Concentration: Not listed | Dosage: One to two pumps nightly | Size: 1 oz | Cruelty-Free: Yes | Byrdie Clean: No

Best for Sensitive Skin: Maelove Moonlight Retinal Super Serum

Maelove Moonlight Retinal Super Serum

Maelove

What We Like
  • Award-winning formula

  • Non-irritating

  • Calms inflammation

What We Don't Like
  • Limited retailers

Moonlight Super Serum contains retinal (short for retinaldehyde), which is believed to be more effective than standard retinol but still plenty gentle. Formulated with reactive complexions in mind, the Super Serum is filled with a medley of other soothing ingredients like aloe, witch hazel, green tea, and squalane.

Price at time of publish: $37

Active Ingredients: Retinal, vitamin C, squalane | Retinol Concentration: 0.11% | Dosage: A few drops daily | Size: 1 oz | Cruelty-Free: Yes | Byrdie Clean: Yes

Best for Dry Skin: CeraVe Skin Renewing Retinol Serum

CeraVe Renewing Retinol Serum
What We Like
  • Budget-friendly

  • Hydrating

  • Replenishes skin barrier

What We Don't Like
  • May leave behind slight residue

If your skin is on the drier side, go with CeraVe (words to live by). In addition to encapsulated retinol, this air-tight pump bottle is filled with ceramides to replenish and protect the skin barrier, plus hydrating humectants like hyaluronic acid and niacinamide.

Price at time of publish: $21

Active Ingredients: Encapsulated retinol, ceramides, hyaluronic acid, niacinamide | Retinol Concentration: Not listed | Dosage: Small amount daily | Size: 1 oz | Cruelty-Free: No | Byrdie Clean: No

Best for Mature Skin: Josie Maran Argan Beta Retinol Pink Algae Serum

Josie Maran Argan Beta Retinol Pink Algae Serum

Ulta

What We Like
  • Noticeable results

  • Non-irritating

  • Moisturizing

What We Don't Like
  • Expensive

  • Small amount

"Retinoids help to decrease wrinkles and brown spots and improve overall skin texture," says Dr. Madfes. If you want noticeable results, reach for this hot pink potion from Josie Maran. It combines retinol with quercetin, plant oils, and squalane to tackle photoaging without irritation.

Price at time of publish: $69

Key Ingredients: Retinol, plant oils, quercetin | Retinol Concentration: 2% | Dosage: A few drops daily | Size: 0.85 oz | Cruelty-Free: Yes | Byrdie Clean: Yes

Best for Acne-Prone Skin: Differin Adapalene Gel 0.1% Acne Treatment

4.8
differin-adapalene-gel-01-at-amazon

Amazon

What We Like
  • Budget-friendly

  • Effective

  • Dermatologist-recommended

What We Don't Like
  • Small amount

  • Not hydrating

Board-certified dermatologist Melissa K. Levin, MD, recommends Differin Adapalene for clearing and preventing breakouts. "This powerful gel is the first FDA-approved acne-treating retinoid that's over the counter," she explains. "It's an absolute game-changer."

Price at time of publish: $15

Key Ingredients: Adapalene | Retinol Concentration: 0.1% | Dosage: Thin layer daily | Size: 0.5 oz | Cruelty-Free: No | Byrdie Clean: No

Differin Adapalene Gel 0.1% Acne Treatment

Byrdie / Bianca Lambert

Best for Uneven Texture: Glossier Universal Pro-Retinol

4.5
Glossier Retinol

Glossier

What We Like
  • Noticeable results

  • Non-irritating

  • Hydrating

What We Don't Like
  • Results take time

If you're dealing with uneven texture or hyperpigmentation, this little tincture from Glossier has your name on it. It contains 0.5 percent "retinyl sunflowerate," a fancy name for a blend of pure retinol and sunflower seed oil. You'll also get a dose of smoothing stevia extract, moisturizing shea butter, and soothing aloe.

Price at time of publish: $35

Key Ingredients: Retinyl sunflowerate, stevia extract, aloe, shea butter | Retinol Concentration: 0.5% | Dosage: One pump nightly | Size: 1.3 oz | Cruelty-Free: Yes | Byrdie Clean: Yes

Best for Fine Lines: Naturium Retinol Complex Serum

Naturium Retinol Complex Serum

Amazon

What We Like
  • Budget-friendly

  • Smoothing

  • Firming

What We Don't Like
  • Texture is slightly gritty

This affordable formula combines micro-encapsulated retinol with retinol alternative bakuchiol to bring you a one-two punch of line-smoothing, wrinkle-preventing, skin-firming, pore-minimizing goodness, plus vitamin C to simultaneously brighten.

Price at time of publish: $20

Key Ingredients: Micro-encapsulated retinol, bakuchiol, linseed oil, vitamin C | Retinol Concentration: Not listed | Dosage: Thin layer daily | Size: 1 oz | Cruelty-Free: Yes | Byrdie Clean: Yes

Best for Beginners: Revision Skincare Retinol Complete 0.5

Revision Skincare Retinol Complete 0.5

Courtesy of Amazon

What We Like
  • Non-irritating

  • Brightening

  • Reduces redness

What We Don't Like
  • Expensive

  • Contains synthetic fragrance

Board-certified dermatologist Julie Russak, MD, is a fan of Retinol Complete, which addresses hyperpigmentation, dark spots, and other signs of photoaging by encouraging cell turnover. "It's formulated with humectant molecules that hydrate and also contains antioxidants," she tells Byrdie. "This makes it much more tolerable and decreases any redness or dryness."

Price at time of publish: $104

Key Ingredients: Retinol, bakuchiol, vitamin C | Retinol Concentration: 0.5% | Dosage: One to two pumps three times a week | Size: 1 oz | Cruelty-Free: Yes | Byrdie Clean: No

Final Verdict

Peter Thomas Roth Fusion PM is, hands down, the best retinol serum. The dermatologist-recommended formula contains 1.5 percent encapsulated retinol, plus brightening antioxidants and moisturizing squalane. However, if you want something a bit more affordable, you can't go wrong with The Inkey List Retinol Serum, an award-winning formula containing two retinoids, squalane, and hyaluronic acid.

What to Look for in a Retinol Serum

Retinol Form

When shopping around, you'll see serums containing various forms of retinol, as well as some other over-the-counter retinoids. Dr. Madfes recommends encapsulated retinol (sometimes called sustained-release retinol), as it offers a slower release into the skin, which helps minimize irritation and excessive dryness.

You'll also find various retinoid complexes, which means multiple forms are combined into one. Then there's retinal (aka retinaldehyde), which has shown to be a little more effective than traditional retinol while still avoiding prescription-level side effects.


Concentration

Over-the-counter formulas usually contain about 1 percent retinol, though you'll find some lower and higher strengths. While OTC serums typically max out at 2 percent, they can go higher, depending on the form of retinoid used. Higher concentrations generally provide faster, more noticeable results, but if you have particularly sensitive skin, a lower concentration may be best.

Hydrating and Soothing Ingredients

Since retinoids can cause dryness, Dr. Madfes says, "the trick is to create a balance to not dry the top layer of our skin." She recommends formulas with hydrating ingredients like hyaluronic acid, glycerin, squalane, niacinamide (vitamin B3), ceramides, and plant oils.

Another common side effect is irritation. To minimize stinging and redness, opt for retinol serums containing soothing ingredients, such as chamomile, aloe, witch hazel, and green tea. Squalane and various plant oils can also offer a calming effect.

FAQ
  • Are retinol serums safe for all skin types?

    "Retinol serums are safe for all skin types," confirms Dr. Madfes. However, if you have sensitive, reactive, or dry skin, look for a formula containing some of the hydrating and soothing ingredients mentioned above.

  • Are retinol serums safe to use while pregnant or breastfeeding?

    "Retinol products are not to be used while pregnant," Dr. Madfes tells Byrdie. To achieve similar smoothing, brightening, complexion-clearing benefits, she says, "Substitute vitamin C, vitamin B, glycolic acid, lactic acid, and antioxidants into your skincare regimen."

  • How often should you apply retinol serums?

    According to Dr. Madfes, a retinol serum should be applied daily, preferably at night. "If you experience dryness, change to every other night," she adds. "It's important to apply sunscreen in the morning to protect and continue the collagen-stimulating benefits."

Why Trust Byrdie

Theresa Holland is a freelance copywriter and self-proclaimed skincare nerd. For this story, she asked a board-certified dermatologist for their serum recommendations and insight into formulations, usage, efficacy, and safety. Before landing on her final selections, she referenced several peer-reviewed studies and pored over ingredients lists. As a long-time retinol user, Theresa has tried a handful of products on this list, including RoC, Dr. Dennis Gross, Neutrogena, Maelove, CeraVe, and Yeouth. She covers skincare, haircare, and makeup at Byrdie.

Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Shields CW, White JP, Osta EG, et al. Encapsulation and controlled release of retinol from silicone particles for topical deliveryJournal of Controlled Release. 2018;278:37-48. doi: 10.1016/j.jconrel.2018.03.023

  2. Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatologyMolecules. 2009;14(1):540-554. doi: 10.3390/molecules14010540

  3. Miraj S, Alesaeidi S. A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile)Electron physician. 2016;8(9):3024-3031. doi: 10.19082/3024

  4. Kim SJ, Baek JH, et al. The effect of physically applied alpha hydroxyl acids on the skin pore and comedoneInt J Cosmet Sci. 2015;37(5):519-525. doi: 10.1111/ics.12244

  5. Mukherjee S, Date A, et al. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safetyClinical Interventions in Aging. 2006;1(4):327-348. doi: 10.2147/ciia.2006.1.4.327

  6. Meckfessel MH, Brandt S. The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care productsJ Am Acad Dermatol. 2014;71(1):177-184. doi: 10.1016/j.jaad.2014.01.891

  7. Shin, Eun Ju et al. Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human SkinInt J Mol Sci. 2019;20(21):E5262. doi:10.3390/ijms20215262

  8. Sarkar R, Arora P, Garg Kv. Cosmeceuticals for hyperpigmentation: What is available? J Cutan Aesthet Surg. 2013;6(1):4. doi: 10.4103/0974-2077.110089

  9. Chaudhuri RK, Bojanowski K. Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. Int J Cosmet Sci. 2014;36(3):221-230. doi: 10.1111/ics.12117

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