14 Best Drugstore Hand Creams to Smooth Dry, Rough Skin

Our editors independently research, test, and recommend the best products; you can learn more about our review process here. We may receive commissions on purchases made from our chosen links.

It’s probably a safe bet to say your hands are feeling drier than normal these days. All that hand washing you’ve been doing can do a serious number on your hands’ delicate skin, not to mention the impacts of dry, cool weather.

“The most common thing that can dry out your hands is frequent hand washing,” says dermatologist Dr. Peterson Pierre. “The constant wet-dry cycle of frequent hand washing can really strip the skin of its natural moisture and disrupt the protective barrier."

That’s why Pierre says it’s important to follow up every handwashing session with a generous application of hand cream. The good news is, you can find a high-quality hand cream right at the drugstore, meaning you don’t have to shell out much money to keep your hands soft and smooth. “You want a product that focuses on replenishing moisture with ingredients such as hyaluronic acid, shea butter, coconut oil, and glycerin,” says Dr. Pierre. “Equally important are ingredients that help repair the moisture barrier, such as ceramides, squalane, and essential fatty acids.” 

Here, we’ve rounded up the best drugstore hand creams for softer, smoother hands. 

Best Overall: CeraVe Therapeutic Hand Cream

Dr. Pierre is a fan of this drugstore hand cream because it’s formulated with two of his favorite ingredients: ceramides and hyaluronic acid. It gets high marks all around for its ability to help your skin retain moisture. It even has a seal of acceptance from the National Eczema Association. Users rave about the non-greasy texture, how quickly it sinks into skin, and how soft and moisturized their hands feel all day long. 

Runner-Up, Best Overall: Cetaphil PRO Eczema Soothing Moisturizer

Dr. Pierre calls this drugstore hand cream/body lotion a “solid choice.” It’s formulated with colloidal oatmeal, a known skin-soother, as well as ceramides, to ease itchy, irritated skin. With a fragrance- and paraben-free formula, this hand cream is suitable for very dry skin, eczema, and atopic dermatitis. Users who wash their hands frequently say it does a great job of keeping their hands moisturized. 

Best Budget: Love Beauty and Planet Murumuru Butter & Rose Hand Cream

Love Beauty and Planet Murumuru Butter & Rose Hand Cream Delicious Glow

Courtesy of CVS

This budget drugstore hand cream might not come with a hefty price tag, but it certainly will look cute on your nightstand. And the high-quality formula means it really deserves its spot there. Inside the pink, rose-adorned tube you’ll find a rich moisturizer featuring murumuru butter. Reviewers love the heavenly, rose scent, and the fact that this hand cream sinks right into skin without any greasy residue. 

Best for Dry Hands: O’Keeffe’s Working Hands Hand Cream

Dry hands need special care. Enter this drugstore hand cream made for extremely dry, cracked hands. It has a super-concentrated formula full of emollients that form a protective layer on the skin to help lock in moisture. Many users with dry hands say this is their go-to, especially in the middle of winter when skin tends to be drier as well as after hand-washing. 

Runner-Up, Best for Dry Hands: Nubian Heritage African Black Soap Hand Cream

Nubian Heritage African Black Soap Hand Cream

Courtesy of Nubian Heritage

Pump up the moisture on dry hands with this drugstore hand cream. It’s chock full of hydrating ingredients such as cocoa seed butter, mango seed butter, and jojoba seed oil. Users note the thick, intensely moisturizing formula that goes on smoothly without being greasy. 

Best for Dry Cuticles: Yes to Coconuts Moisturizing Hand & Cuticle Cream

One of the most frustrating side effects of dry hands? Dry cuticles. This drugstore hand cream is formulated to tackle exactly that issue. It’s loaded with coconut oil and shea butter to help smooth ragged cuticles and heal dry, cracked skin. Users highlight the rich yet non-greasy texture in addition to the sweet yet not overbearing coconut scent. 

Best Anti-Aging: Neutrogena Hydro Boost Hand Gel Cream

Neutrogena Hydro Boost Hand Gel Cream

 Courtesy of Ulta

When it comes to anti-aging skin care, it doesn’t hurt to pay attention to your hands. After all, the delicate skin there is often one of the first areas to show signs of aging. This drugstore hand cream keeps hands looking young, thanks to hyaluronic acid. This super-star ingredient is an anti-aging mainstay due to its ability to retain moisture and make skin look plumper. 

Best for Eczema: Gold Bond Eczema Relief Hand Cream

Those with eczema know how amazing it feels to find relief. This drugstore hand cream provides just that. It has an ultra-soothing formula that targets five common eczema symptoms: itchiness, dryness, peeling, roughness, and redness. Users rave about how soft this makes their hands feel and how good a job it does of easing eczema-related itch. 

Best Fragrance-Free: Zandra Simplicity Hand+Body Lotion - Unscented

Inside this chic pump bottle lies an unscented drugstore hand cream that does an excellent job at moisturizing hands. It’s made with nourishing jojoba oil and absorbs quickly into the skin. And because it’s fragrance-free, it’s suitable for use by sensitive skin types. 

Runner-Up, Best Fragrance-Free: Dove Dry Skin Relief Replenishing Hand Cream

Dove Dermaseries Dry Skin Relief Replenishing Hand Cream

 Courtesy of Walmart

This fragrance-free drugstore hand cream is ideal for extremely dry, itchy skin. Beyond being fragrance-free, it’s also hypoallergenic, non-greasy, and very lightweight. Users say this hand cream sinks into the skin quickly, nourishes their cuticles, and keeps their hands moisturized for hours. 

Best with SPF: Eucerin Daily Hydration Hand Cream SPF 30

One of the best ways to protect your hands from aging is to slather on a hand cream with SPF in it. This drugstore hand cream is the perfect pick. It’s got SPF 30 to shield your skin from sun damage and is also formulated with licorice root extract to soothe dryness. 

Best Fast-Absorbing: Palmer’s Cocoa Butter Formula Hand Cream

Palmer’s Cocoa Butter Formula Hand Cream

Courtesy of Palmer's

Don’t you hate when you apply hand cream and it leaves you all sticky? You won’t have to deal with that when you use this drugstore hand cream. It has a fast-absorbing, lightweight formula that’s perfect for normal to dry skin. Vitamin E helps promote softer, smoother hands. 

Best for Hand and Body: Alaffia Coconut Reishi Moisturizing Hand & Body Lotion

Get to multitasking with this drugstore hand cream that doubles as a body lotion. It’s formulated with a slew of moisturizing ingredients, like yarrow extract, coconut oil, and reishi mushroom extract, that’ll soften and smooth hands and other rough areas. Users note that a little goes a long way and that it sinks in quickly. 

Best Natural: Urban Hydration Rosehip Hand Cream

Urban Hydration Rosehip Hand Cream

Courtesy of Urban Hydration

If you’re looking for a natural solution to heal dry hands, then look no further than this drugstore hand cream. The natural formula contains coconut oil, rosehip seed oil, and glycerin to soothe irritated skin and bring back much-needed moisture. Beyond the formula, users like the subtle and pleasant scent.

To get the most out of your drugstore hand cream, Dr. Pierre shares this advice: “After you wash your hands, pat them dry so they’re still a little damp and seal in that moisture with your favorite hand cream.”

Related Stories