The Best Acne Products to Clear and Prevent Breakouts

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Breakouts are inevitable, but especially during times of stress. So, it's no surprise 2021 has led to it's fair share of pimples cropping up on our (usually masked) faces. "In times of stress, your stress hormones rise and trigger your oil glands to produce more oil, which then triggers acne flares,” Donna Hart, M.D., FAAD, a board-certified dermatologist at Westlake Dermatology in Austin, Texas, explains.

To figure out how to best proceed—i.e. using helpful, effective products to target and heal breakouts without feeling bad about our skin—we did some research. We tested, reviewed, and wrote everything down. Below, find the best acne products to tackle blemishes at any stage and in any situation.

Best for Clogged Pores: Drunk Elephant T.L.C. Framboos Glycolic Night Serum

Drunk Elephant T.L.C. Framboos Glycolic Night Serum

Drunk Elephant

This ingredient-packed serum uses a potent combination of exfoliating acids, pore cleaners, antioxidants, and moisturizers to create an overnight treatment that operates like a gentler version of a glycolic acid peel. Expect a tingling sensation when you apply—that’s this serum sloughing off dead skin cells, unclogging pores, and evening out your skin tone while you sleep to help minimize the likelihood and duration of breakouts over time. Pro tip: Avoid using this serum in combination with other acne spot treatments.

Best Retinoid: Differin Adapalene Gel 0.1% Acne Treatment

Differin Adapalene Gel 0.1% Acne Treatment

Courtesy of Walmart

Formerly available by prescription only, Differin is now for sale over the counter, and serious skincare gurus are overjoyed. It contains a prescription-strength retinoid called Adapalene, which dermatologists recommend specifically for the treatment of acne. Long story short: It’s more than worth a try. The water-based formula is free of oil, alcohol, and fragrance, and is an essential item in anyone’s acne-fighting arsenal.

Best Patch: COSRX Acne Pimple Master Patch

Cosrx Master Pimple Patch

 Courtesy of Amazon

If you have a pimple that’s inflamed and you want to bring it down fast, these patches are a perfect overnight fix. Much like a bandage, hydrocolloid patches help the acne medication penetrate deeper into the skin by keeping it where it’s needed—no rubbing off on your pillow. The patch environment keeps the skin moist and permeable while keeping out bacteria. They have an almost magical ability to flatten even the worst zits and reduce their appearance quickly.

cosrx acne pimple master patch

Byrdie / Bianca Lambert

What Our Testers Say

"I wasn't expecting a quick fix the next morning, but I am happy to report that while the pimple wasn't gone, it was significantly smaller. I count this as a win in my book. I don't believe in overnight skincare treatments, but these patches changed my mind." — Bianca Lambert, Product Tester

Best Spot Treatment: Mario Badescu Drying Lotion


Key Ingredients

Sulfur is a natural element that is an essential component for all living cells. Sulfur-based products tend to work best for mild-to-moderate acne, primarily whiteheads, blackheads, and papules.

Ask any woman who’s ever struggled with acne and she’ll at least have heard of this cult acne-fighter. People swear that just one drop of Mario Badescu’s famous drying lotion can heal and dry a zit up overnight; the calamine, colloidal sulfur, and salicylic acid ensure it.

mario badescu drying lotion

Byrdie / Bianca Lmabert

What Our Testers Say

"Mario Badescu's Drying Lotion does just what it says: stops pimples in their tracks and calms them at the same time." — Bianca Lambert, Product Tester

Best Natural: Marla Rene Beauty & Co. Calendula Clear Serum

Marla Rene

Key Ingredients

Aloe vera is a naturally derived ingredient known for its soothing and moisturizing properties. The aloe plant's inner gel mucilage (the part that's used in skincare products) is made up of 99.5% water.

This clarifying serum is 100% natural and plant-based to gently calm irritated and acne-prone skin. It has aloe vera to increase skin's elasticity and restore its optimum pH balance, and alcohol-free witch hazel to control oil production and prevent future breakouts. The real star ingredient is calendula, which promotes the fast healing and regeneration of skin.

Runner-Up, Best for Acne Scars: Mary Louise Miracle Serum

My Mary Louise

If you've tried everything for your acne scars to no avail, this might be the serum for you. This vegan and cruelty free product is super packed with nutrients to target several skincare concerns, including acne scars, eczema, razor bumps, hydration, and hyperpigmentation. It absorbs quickly into skin for a non-greasy finish, and we especially love that this serum plays nicely under skincare.

Users say that it has anti-inflammatory properties and gave them a clearer, glowing complexion.

Best Mask: Aztec Secret Indian Healing Clay

Aztec Secret – Indian Healing Clay

Key Ingredients

Apple cider vinegar is fermented apple juice formed by when yeast mixes with the sugar of the juice. It contains acetic acid, which has antibacterial and keratolytic properties, and it also contains malic acid, a gentle chemical exfoliant.

Not only is this cult product a major bargain, but it works like magic for super-oily problem skin. Mix the bentonite clay-based formula with water (or apple cider vinegar) and apply it to your face like a mask—the clay will soak up excess oils and debris, leaving your face feeling soft, fresh, and clean.

Aztec Secret Indian Healing Clay

Byrdie / Bianca Lambert

Best for Cystic Acne: Renée Rouleau Anti Bump Solution

Renée Rouleau Anti Bump Solution

Stubborn cystic acne (those painful red bumps that never quite come to a head) is particularly hard to treat, as the zit itself is hidden deep under the surface of the skin. This cult-favorite cystic acne treatment from celebrity esthetician Renee Rouleau uses lactic acid to purify your pores, methyl gluceth 20, which helps moisturize, and citric acid to help with hyperpigmentation and scarring. Apply it immediately when you feel a cyst developing, and it will help reduce the inflammation and duration of the blemish.

Best Serum: Evologie Intensive Blemish Serum

Evologie Intensive Blemish Serum

Courtesy of Amazon

The top-selling acne product online comes from doctor-developed brand Evologie. Its patent-pending YS3 Complex uses azelaic acid and salicylic acid to banish breakouts deep below the skin's surface, also brightening hyperpigmentation and acne scars. In other words, this might just be the miracle product you’ve been praying for.

Best LED: Foreo Espada

Foreo Espada Acne-Clearing Blue Light Pen

Courtesy of Ulta 

If creams and gels aren't your thing, light therapy is also effective at treating acne—and fast, too. This Foreo device uses a combo of laser-focused blue LED light and T-Sonic pulsations to fight acne-causing bacteria in just 30 seconds. It's also totally waterproof, and according to the brand, you can use it up to 100 times per charge. Just press the center button, point the device at your blemish using the targeting red light, and hold for 30 seconds; you can repeat this up to four times for a stronger treatment.

Best for Body: Paula's Choice Clear Acne Body Spray

Paula’s Choice Clear Acne Body Spray

Courtesy of Paula’s Choice

Looking to treat hard-to-reach areas of the body (like your back)? Grab this Paula's Choice spray-on body exfoliant, which contains 2% salicylic acid to fight blemishes, bumps, and blackheads, as well as licorice root (to calm irritated skin) and barberry (which is antibacterial and anti-inflammatory). This product is also alcohol-free and dries quickly, so you can spray it on and go.

Best for Hyperpigmentation: Kiehl's Clearly Corrective Dark Spot Solution

Kiehl’s Clearly Corrective Dark Spot Solution

Courtesy of Kiehl's

Post-inflammatory hyperpigmentation (ie. pesky dark spots and discoloration that can crop up post-breakout) is super common—even more so for those with darker skin tones. The good news? This lightweight Kiehl's solution can help, ASAP. Activated C, a fast-acting form of vitamin C, works to reduce the appearance of dark spots while peony extract shields against oxidative damage. Clearer skin, coming right up.

Best for Blackheads: Glossier Solution


 Courtesy of Glossier

While pore strips may seem satisfying, they can actually cause more harm than good when it comes to treating blackheads. Glossier's Solution, a liquid exfoliator, is an alternative we love. It improves the appearance of blemishes with a 10% blend of skincare acids (salicylic acid, alpha-hydroxy acids, and polyhydroxy acid), while aloe, glycerin, and niacinamide hydrate and calm the skin. It's also dermatologist-tested, cruelty-free, and vegan.

Glossier Solution

Byrdie / Jenna Igneri

What Our Testers Say

"Spots that felt rough or bumpy were smoother, and the blackheads around my nose started to disappear. By the end of the four weeks, my complexion was a lot less dull and looked overall much healthier and radiant." — Jenna Igneri, Product Tester

Best Overnight Spot Treatment: Rosen Skincare Break-Out

Rosen Skincare Break-Out Spot Treatment

 Courtesy of Urban Outfitters

This product looks a bit like Wite-Out, but it's not just a way to cover blemishes—it works to shrink and heal them overnight. The hero of its innovative formula is zinc oxide, which helps combat redness, irritation, and inflammation. From there, peppermint oil, which is antiseptic and anti-microbial, cools and calms the skin, and apple cider vinegar, which is anti-bacterial, helps prevent further breakouts. For clearer skin in the morning, apply to a problem area before you snooze.

Best Gel Moisturizer: Clinique Acne Solutions Clinical Clearing Gel

Clinique Acne Solutions Clearing Gel

Courtesy of Ulta

This salicylic acid acne treatment has been a fan favorite for years and guess what: It's still available and still highly effective. Depending on your skin’s needs, you can apply a thin layer twice a day after you cleanse your skin, or if you already use an all-over acne treatment, you can use it as a spot treatment on particularly stubborn zits. The ultra-simple formula is hypoallergenic as well as fragrance-, oil- and paraben-free. Win, win, win.

Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Berson D, Alexis A. Adapalene 0.3% for the treatment of acne in womenJ Clin Aesthet Dermatol. 2013;6(10):32-35.

  2. Kuo CW, Chiu YF, Wu MH, et al. Gelatin/Chitosan Bilayer Patches Loaded with Cortex Phellodendron amurense/Centella asiatica Extracts for Anti-Acne ApplicationPolymers (Basel). 2021;13(4):579. doi:10.3390/polym13040579

  3. Liu H, Yu H, Xia J, et al. Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acneCochrane Database Syst Rev. 2020;5(5):CD011368. doi:10.1002/14651858.CD011368.pub2

  4. Arif T. Salicylic acid as a peeling agent: a comprehensive reviewClin Cosmet Investig Dermatol. 2015;8:455-461. doi:10.2147/CCID.S84765

  5. Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic ReviewIran J Med Sci. 2019;44(1):1-9.

  6. Hamman JH. Composition and applications of Aloe vera leaf gelMolecules. 2008;13(8):1599-1616. doi:10.3390/molecules13081599

  7. Chularojanamontri L, Tuchinda P, Kulthanan K, Pongparit K. Moisturizers for Acne: What are their Constituents?J Clin Aesthet Dermatol. 2014;7(5):36-44.

  8. Arora D, Rani A, Sharma A. A review on phytochemistry and ethnopharmacological aspects of genus CalendulaPharmacogn Rev. 2013;7(14):179-187. doi:10.4103/0973-7847.120520

  9. Lee NR, Lee HJ, Yoon NY, Kim D, Jung M, Choi EH. Application of Topical Acids Improves Atopic Dermatitis in Murine Model by Enhancement of Skin Barrier Functions Regardless of the Origin of AcidsAnn Dermatol. 2016;28(6):690-696. doi:10.5021/ad.2016.28.6.690

  10. Tang SC, Yang JH. Dual Effects of Alpha-Hydroxy Acids on the SkinMolecules. 2018;23(4):863. doi:10.3390/molecules23040863

  11. Williams LB, Haydel SE. Evaluation of the medicinal use of clay minerals as antibacterial agentsInt Geol Rev. 2010;52(7/8):745-770. doi:10.1080/00206811003679737

  12. Johnson W Jr, Heldreth B, Bergfeld WF, et al. Safety Assessment of Methyl Glucose Polyethers and Esters as Used in CosmeticsInt J Toxicol. 2016;35(2 suppl):12S-40S. doi:10.1177/1091581816670322

  13. Evologie. YS3 Complex.

  14. Scott AM, Stehlik P, Clark J, et al. Blue-Light Therapy for Acne Vulgaris: A Systematic Review and Meta-AnalysisAnn Fam Med. 2019;17(6):545-553. doi:10.1370/afm.2445

  15. Sarkar R, Arora P, Garg KV. Cosmeceuticals for Hyperpigmentation: What is Available?J Cutan Aesthet Surg. 2013;6(1):4-11. doi:10.4103/0974-2077.110089

  16. Neag MA, Mocan A, Echeverría J, et al. Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal DisordersFront Pharmacol. 2018;9:557. doi:10.3389/fphar.2018.00557

  17. Kiehl's. The Skin Benefits of Activated C.

  18. Lu YS, Jiang Y, Yuan JP, et al. UVA Induced Oxidative Stress Was Inhibited by Paeoniflorin/Nrf2 Signaling or PLIN2Front Pharmacol. 2020;11:736. doi:10.3389/fphar.2020.00736

  19. Health Essentials Cleveland Clinic. How to Get Rid of Blackheads.

  20. Kornhauser A, Coelho SG, Hearing VJ. Effects of cosmetic formulations containing hydroxyacids on sun-exposed skin: current applications and future developmentsDermatol Res Pract. 2012;2012:710893. doi:10.1155/2012/710893

  21. Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic ReviewIran J Med Sci. 2019;44(1):1-9.

  22. Bains P, Kaur M, Kaur J, Sharma S. Nicotinamide: Mechanism of action and indications in dermatologyIndian J Dermatol Venereol Leprol. 2018;84(2):234-237. doi:10.4103/ijdvl.IJDVL_286_17

  23. Gupta M, Mahajan VK, Mehta KS, Chauhan PS. Zinc therapy in dermatology: a reviewDermatol Res Pract. 2014;2014:709152. doi:10.1155/2014/709152

  24. Singh R, Shushni MAM, Belkheir A. Antibacterial and antioxidant activities of Mentha piperita L. Arabian Journal of Chemistry. 2015;8(3):322-328. doi:10.1016/j.arabjc.2011.01.019

  25. Elsaie LT, El Mohsen AM, Ibrahim IM, Mohey-Eddin MH, Elsaie ML. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritusClin Cosmet Investig Dermatol. 2016;9:333-338. doi:10.2147/CCID.S116995

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