Despite the variety of pivotal roles vitamin B6 plays in our bodies, it feels like it's been unfairly neglected in the realm of supplements and wellness—especially in comparison to its B vitamins sisters biotin and B12. After all, the benefits of vitamin D, fish oil, and even trendier supplemental fares like adaptogens and CBD are touted to the world's end and back, but vitamin B6? Crickets comparably. However, after getting hints here and there from nutritionists and other health experts we've talked to, we're beginning to understand just how important sufficient B6 intake is, and all the different benefits and roles it plays in the healthy maintenance of our bodies.
In fact, on a more personal note, it wasn't until I was experiencing some icky hormonal and sleep issues that I realized just how pivotal vitamin B6 is when it comes to maintaining healthy and happy nervous, immune, and metabolic systems. "While all B vitamins help your body to metabolize the nutrients in the food you eat, as well as break down fats and proteins, vitamin B6 is particularly important for hormonal health," holistic nutritionist and hormone expert Alisa Vitti explains on her website. In other words, vitamin B6 is especially important for women.
Of course, high-quality supplements are great ways to ensure you're getting ample vitamin B6 levels (most adults need at least 1.3 milligrams of vitamin B6 daily to prevent deficiency), but getting the vitamin by way of pure whole-food sources are generally preferred. Plus, since vitamin B6 is water-soluble, anything your body doesn't utilize is naturally excreted versus stored in the body. Thus, a consistent stream of this vitamin is crucial in order to prevent deficiency. (For the record, wild-caught tuna fish, bananas, spinach, pistachios, sweet potatoes, pinto beans, sunflower seeds, sesame seeds, turkey, grass-fed beef, and chicken are all recommended food sources from Vitti.) We were curious to know more about why our bodies love vitamin B6 so much.
Ahead, we cover 10 of the most important vitamin B6 benefits in addition to expert-approved supplements.
1. Healthy Blood Vessels
A quick lesson in blood health 101: Homocysteine is a type of amino acid the body receives via protein-rich food sources, but when levels of the amino acid get too high, it can be a potential risk of inflammation, heart disease, and other cardiovascular complications posing risk down the line. That said, studies have shown adequate amounts of B6 in combination with folate can significantly help lower levels of total homocysteine in the body.
2. Brain Function
As research points out, ample levels of B6 play a pivotal role in brain glucose function. Essentially, the vitamin encourages the proper function and development of the brain and nervous system, and some studies say deficiency could influence diseases like Alzheimer's and dementia as time goes on and we begin to age.
3. Smoother Hormone Function
"Vitamin B6 is a particularly important vitamin that can help boost progesterone production to counteract excess estrogen—a top cause of hormonal dysfunction," explains Vitti. "B6 supports the development of the corpus luteum, which is where all your progesterone originates, and it also works with your liver enzymes to remove excess estrogen from the body and boosts the immune system."
4. Mood Improvement
According to research, vitamin B6 has a significant impact on the central production of both serotonin and GABA neurotransmitters in the brain, which are important compounds for mood regulation, in addition to depression, pain, fatigue, and anxiety prevention.
5. Anemia Treatment
If you're already suffering from anemia, increasing vitamin B6 can help diminish symptoms of the condition like fatigue, weakness, body aches, and more.
6. Eye Health
Not to scare you, but macular degeneration is one of the leading causes of vision loss around the world. The good news? Prioritizing a nutrient diet is one of the best expert-approved ways of keeping eyesight on point and potential eye diseases at bay. Specifically, certain studies have shown supplementing vitamin B6 in conjunction with other vitamins like folate can aid in optimum eye health.
7. Arthritis Management
As pointed out in a study, a deficiency in vitamin B6 has been associated with increased symptoms of rheumatoid arthritis and other pain-related complications. If supplemented, vitamin B6 may benefit the disease by reducing inflammation, thus alleviating swelling and other common signs and symptoms of rheumatoid arthritis.
8. Relieve & Manage PMS
As we mentioned earlier, vitamin B6 plays a major role in regard to our hormones. Thus, it doesn't come as a huge surprise that adequate levels of the vitamin might benefit those who suffer from killer PMS symptoms, specifically breast pain, nausea, cramps, fatigue, and headaches. Plus, it might even help reduce the skin's propensity to break out pre-period.
"It's believed vitamin B6 helps with PMS because of its positive effects on specific neurotransmitters that are responsible for pain management in the brain as well as its ability to increase blood flow and manage hormones," says Dr. Axe. "It's recommended for women who experience frequent PMS symptoms to take B complex vitamins regularly, especially in the 10 days before menstruating."
9. Healthier Sleep Cycles
You've likely heard about melatonin and the important role it plays in a healthful sleep routine. Well, as it turns out, vitamin B6 helps the body make melatonin. Therefore, if you're deficient in the vitamin, it might cause an issue with the quality of your sleep.
10. Reduced Morning Sickness
According to studies, vitamin B6 might help relieve common symptoms of pregnancy like morning sickness and nausea. In fact, one study demonstrated that after tracking their nausea before taking vitamin B6 and then again afterward, the group of patients who took vitamin B6 felt significantly less nauseous compared in comparison to the placebo group.
U.S. Department of Health and Human Services. Vitamin B6.” NIH Office of Dietary Supplements.
Pietrzik K, Brönstrup A. https://www.doi.org/10.1007/pl00014298. Eur J Pediatr. 1998;157 Suppl 2:S135-8. doi:10.1007/pl00014298
Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016;8(2):68. doi:10.3390/nu8020068
Tong Y. Seizures caused by pyridoxine (vitamin B6) deficiency in adults: A case report and literature review. Intractable Rare Dis Res. 2014;3(2):52-6. doi:10.5582/irdr.2014.01005
Yasuda H, Fujiwara N, Ishizaki Y, Komatsu N. Anemia attributed to vitamin B6 deficiency in post-pancreaticoduodenectomy patients. Pancreatology. 2015;15(1):81-3. doi:10.1016/j.pan.2014.12.001
Kang JH, Loomis SJ, Wiggs JL, Willett WC, Pasquale LR. A prospective study of folate, vitamin B₆, and vitamin B₁₂ intake in relation to exfoliation glaucoma or suspected exfoliation glaucoma. JAMA Ophthalmol. 2014;132(5):549-59. doi:10.1001/jamaophthalmol.2014.100
Huang SC, Wei JC, Wu DJ, Huang YC. Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. Eur J Clin Nutr. 2010;64(9):1007-13. doi:10.1038/ejcn.2010.107
Kashanian M, Mazinani R, Jalalmanesh S. Pyridoxine (vitamin B6) therapy for premenstrual syndrome. Int J Gynaecol Obstet. 2007;96(1):43-4. doi:10.1016/j.ijgo.2006.09.014
[Pyridoxine (vitamin B6) influence on endogenic melatonin production during the experiment]. Georgian Med News. 2007;(153):35-8.
Sahakian V, Rouse D, Sipes S, Rose N, Niebyl J. Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. Obstet Gynecol. 1991;78(1):33-6.