Allantoin: The Soothing Skincare Ingredient You Should Get to Know

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Liz deSousa for BYRDIE

In the beauty world, we're a little guilty of over-hyping some ingredients and skincare products while overlooking others that deserve a little more praise. Take allantoin for instance. If you don't know much about it or haven't even heard of it, you're not alone. Despite all of its skin benefits—including moisturizing and soothing—allantoin flies pretty far under the radar. Because we think it deserves a little more recognition, we spoke to two dermatologists who helped us get acquainted with the skin-loving ingredient before it becomes the next beauty buzzword.

Meet the Expert

  • Ava Shamban, MD, is a dermatologist based in Beverly Hill, who specializes in wrinkle reduction and other aesthetic skincare procedures.
  • Jennifer Herrmann, MD, FAAD, is a board-certified dermatologist specializing in lasers, Mohs surgery, cosmetic fillers, and Botox.

Find out everything you need to know about the benefits of allantoin below.


Type of ingredient: Moisturizer and exfoliator.

Main benefits: Moisturizes, soothes itchiness, and heals injured skin.

Who should use it: In general, those with dry, itchy skin looking for better skin texture and smoothness, regardless of skin type, age, or conditions.

How often can you use it: Can be used day in and day out without general side effects of any kind, according to Shamban.

Works well with: Herrmann says when used in scar creams, allantoin is often combined with ingredients like silicone and other emollients to amplify results.

Don't use with: Herrmann adds that combining it with other exfoliants could produce an exaggerated reaction, causing excess irritation, if strengths are too high.

What Is Allantoin?

Allantoin, also known as aluminum dihydroxy allantoinate, is an extract from the comfrey plant, which is native to temperate climates of Asia and Europe. According to Herrmann, it has potent healing and soothing properties, and for centuries comfrey leaves were used to help heal minor skin injuries and swelling. Additionally, it can be found in a variety of plants such as beets, chamomile, wheat sprouts, and even tobacco seeds. Shamban adds that although it can be extracted for cosmetic usages from most of these sources, more often it's the lab-created versions we find in products. "Both versions are safe and effective when used in advanced skincare and are becoming more and more popular for efficacy and results," Shamban says.

Allantoin comes in powder form and is found in many creams and liquids such as moisturizers, exfoliators, and masks. "Although rigorous scientific studies are lacking, there is anecdotal evidence that it helps moisturize the skin by exfoliating and removing dead skin cells that prevent natural humectants from binding and retaining water in the skin," Herrmann says.

Benefits of Allantoin for Skin

Allantoin is multipurpose and as Shamban puts it, "the kind of employee you want on your team—one who can multitask and with a full range of talents." Below, are eight ways allantoin can improve your skin.

  • Moisturizes: Allantoin acts as an emollient that keeps your skin moisturized and prevents dryness and irritation.
  • Soothes skin: Allantoin has the additional functionality of being a calming agent. It soothes and protects the skin by forming complexes with irritant and sensitizing agents, according to Herrmann.
  • Improves skin-healing: Herrmann says it has been noted to help soothe injured skin and promote wound healing and is often used to treat skin irritation and rashes.
  • Exfoliates: Herrmann adds that allantoin is also keratolytic, which means it exfoliates dead skin cells. As explained by Shamban, it helps desquamation, the shedding of the outermost membrane or layer of tissue from the inside out. 
  • Hydrates: Shamban says its keratolytic property can increase the water contents of cells, therefore, fighting against the damage of transepidermal water loss (TEWL) in the dermis, which keeps the skin looking plump and youthful. "Think of it as almost the expansion of a sponge when wet, holding the maximum amount of liquid," she says.
  • Improves skin dullness: Allantoin promotes cell proliferation and supports overall "remodeling," as Shamban puts it. "If the skin is stressed by the usual and customary list of offenders, then the skin is going to try to repair itself as opposed to having more cells turn over," she explains. "What we want to do with the epidermis is to have it constantly exfoliating itself and having more cells be produced because that’s how you get a faster transit time of the epidermal cells. As people get older, then that transit time from the base layer of the epidermis to the top layer takes longer, and also the skin is stressed, and those are some of the causes of dull, dry skin, too. This is going to help with that cell proliferation."
  • Smoothes skin: Herrmann says removing surface dead skin cells (stratum corneum), also helps keep the skin smooth and soft.
  • Rejuvenates the cells: Although it's gentle, it can still be an effective anti-aging ingredient. "Allantoin is highly beneficial in facilitating collagen synthesis," Shamban says. "As it stimulates the fibroblasts (cells responsible for producing collagen), it also boosts extracellular matrix synthesis, which is why it is a strong rejuvenator."

Side Effects of Allantoin

In general, allantoin is non-toxic and safe for cosmetic use. "It's non-irritating, it is a gentle anti-ager in skincare and is good for most skin types, including sensitive skin or those with a range of skin conditions, because it has the additional functionality of being a calming agent," Shamban says. But Herrmann adds that it is possible for some people to be allergic to the ingredient, especially if used directly from crushed comfrey leaves, in which case it should be avoided.

How to Use It

Herrmann says because of its varied uses, allantoin should be applied according to how the product containing it directs. Shamban adds that generally, it's safe to use the ingredient on a daily basis.

The Best Products With Allantoin

Skinbetter Science AlphaRet Overnight Cream
SkinBetter Science AlphaRet Overnight Cream 30ML $130.00

You'll be hard-pressed to find a beauty editor who doesn't rave about this impressive overnight cream. It strikes the perfect balance of effective exfoliation (with a powerful combination of retinoids and alpha-hydroxy acids) without the irritation (thanks to the soothing allantoin and niacinamide), which is why it's Shamban's top product recommendation. "The allantoin compounds such as allantoin glycyrrhetinic acid, which can mimic the effects of naturally-occurring allantoin, provide moisturizing and skin-nourishing benefits," Shamban says.

Derma E Scar Gel
Derma E Scar Gel $15.00

Taking full advantage of allantoin's wound-healing benefits, this scar gel works to soften the texture and discoloration of skin injuries. With the added ingredient panthenol (provitamin B5), it promises to effectively smooth and rebuild scars, and it comes highly recommended by Herrmann for that very reason.

Aveeno Therapeutic Shave Gel
Aveeno Therapeutic Shave Gel $4.00

Allantoin is attainable for all budgets, and this ultra-affordable shave gel by Aveeno is the very proof of that. For those who commonly experience irritation when shaving, this formula is a must-try. "Allantoin in addition to aloe and oatmeal work synergistically to make this shave gel especially soothing for sensitive skin," Herrmann says.

Dr. Barbara Sturm Brightening Serum
Dr. Barbara Sturm Brightening Serum $310.00

What makes this serum worth the hefty price tag is its ability to address a wide range of concerns from pigmentation to dehydration and irritation. "Its combination of potent antioxidants helps reduce pigmentation naturally while allantoin helps soothe and keep skin calm," says Herrmann. In addition to those ingredients, it also contains cress sprout extract meant for brightening benefits, plus an extra dose of hyaluronic acid meant for hydration.

Simple Kind to Skin Soothing Shower Cream
Simple Kind to Skin Soothing Shower Cream $19.00

Some shower gels and soaps can strip the skin and leave it feeling tight and dry, but this creamy body wash, which contains allantoin, chamomile, provitamin B5, and vitamin E, does the opposite and soothes the skin as it cleanses. It's one of Herrmann's top picks for its ability to gently exfoliate and brighten even the most sensitive skin.

First Aid Beauty Ultra Repair Cream
First Aid Beauty Ultra Repair Cream $38.00

This rich moisturizing cream feels incredibly nourishing and hydrating on compromised skin, which comes as no surprise considering its soothing and replenishing ingredients: allantoin, oatmeal extract, and ceramides. It's designed for those with severe dryness or flakiness from psoriasis, eczema, keratosis pilaris, and dermatitis, which is why you'll find it on Byrdie's top moisturizers for sensitive skin.

Embryolisse Hydra-Masque
Embryolisse Hydra-Masque $25.00

It's no secret that Byrdie editors are obsessed with this French skincare brand, but this mask, in particular, stands out for its intense hydration and ability to restore a dull complexion, thanks to ingredients like allantoin, hyaluronic acid, and panthenol. Not only does it create the look of healthy, glowy skin, but the mask also goes a step further to repair the skin barrier and lock in the replenished moisture.

  • Is allantoin safe for sensitive skin?

    Allantoin is an emollient and calming agent, and, therefore, safe for sensitive skin.

  • Can allantoin be used on acne-prone skin?

    As it helps remove surface dead skin cells, allantoin can help exfoliate acne-prone skin.

  • Can allantoin be used on dry skin?

    Because of its keratolytic property, allantoin can increase the water contents of cells, keeping skin hydrated, plump, and youthful.

Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Savić VLj, Nikolić VD, Arsić IA, et al. Comparative study of the biological activity of allantoin and aqueous extract of the comfrey rootPhytother Res. 2015;29(8):1117-1122. doi:10.1002/ptr.5356

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